Analysis ofβ2-microglobulin mediated signaling in renal cell carcinoma growth and its bone metastasis

点击翻译按钮获取中文摘要

This study demonstrates for the first time howβ2-microglobulin(β2-M) supports lethal metastasis in vivo in human renal cancer cells(SN12C).β2-M mediates this process by activating epithelial to mesenchymal transition(EMT) to promote lethal bone and soft tissue metastases in host mice. These results demonstrate the role ofβ2-M in renal cancer metastasis and lethality. Thus,β2-M and its downstream signaling pathways are promising prognostic markers of renal cancer metastases and novel therapeutic targets for cancer therapy using anti-β2-M antibody.