The elucidation of the kidney stone formation mechanism from a microstructural change and the oxidative stress of the renal tubular epithelial cell.

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In the early period of kidney stone formation the relations the renal tubular epithelial cell and the cell injury did not become clear until now. However, we clarified it in this study. We clarified the cell injury related mitochondria in the renal tubular cell, and importance of osteopontin relation in the early period of kidney stone formation. For these results of this study, a possibility of a new kidney stone therapy was recognized through the cell injury inhabitation by mitochondrial protection and the control of the osteopontin expression.