Efficacy of paclitaxel incorporated into EGF-conjugated MPC polymer for bladder cancer

将紫杉醇掺入 EGF 缀合的 MPC 聚合物中治疗膀胱癌的疗效

• 批准号: 21791528
• 负责人: TAMURA Koetsu
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791528/
• 关键词: 膀胱癌; ドラッグデリバリー; 抗癌剤; 癌

We evaluated the effect of intravesical administration of paclitaxel incorporated nanoparticles which were prepared for better paclitaxel uptake to cancer cell. In orthotopic mouse model of bladder cancer, there was no significant difference in the effect of paclitaxel incorporated nanoparticles and conventional paclitaxel. Further improvement in paclitaxel uptake seemed to be necessary.

我们评估了紫杉醇掺入纳米颗粒膀胱内给药的效果，所述纳米颗粒是为了更好地将紫杉醇摄取到癌细胞而制备的。在原位小鼠膀胱癌模型中，紫杉醇掺入纳米颗粒的效果与常规紫杉醇没有显著差异。紫杉醇摄取的进一步改善似乎是必要的。