Changes of excitability to mechanical stretch in bladder smooth muscle and its effect to OAB.

我们用细胞内膜电位记录、细胞内钙离子浓度记录技术研究了平滑肌的生理功能。在这一时期，我们的目的是研究机械拉伸的时间依赖性变化引起的膀胱平滑肌兴奋性的变化。尽管当肌条逐渐拉伸时，自发动作电位的频率似乎有所增加，但即使是牵拉也很难连续记录，我们将继续研究机械牵拉记录平滑肌条自发收缩的效果。

We have examined physiological functions of smooth muscles using a technique of intracellular membrane potential recording, intracellular Ca2+ concentration recording. In this time, we aimed to study the changes of excitability caused by time-dependent change of mechanical stretch in the bladder smooth muscle. Although the frequency of spontaneous action potentials seemed to be increased when the smooth muscle was stretched gradually, it was very difficult to record continuously in spite of stretching.We will continue to study to understand the effect of mechanical stretch recording spontaneous contractions of smooth muscle strips.