Analysis of the cell cycle in infected culture cell of Neisseria gonorrhoeae.

淋病奈瑟菌感染培养细胞的细胞周期分析。

• 批准号: 21791535
• 负责人: SHIMUTA Ken
• 金额: $ 2.66万
• 依托单位: National Institute of Infectious Diseases
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791535/
• 关键词: 淋菌感染症; 細胞周期; 尿路感染症

In this study, I confirmed the universality of G1 arrest caused by gonococcus infection in culture cell. I examined about the G1 arrest ability of various strains varied by MLST analysis. The host cell used HeLa cell. In the strain of 40 different phylesis, there was not the strains which significantly caused G1 arrest. Significant difference slightly examined a quantitative alteration of the cytokine production about approved two strains, but the significant difference between the strains was not recognized. These results indicated that the possibility that the G1 arrest in the gonococcus infection cell was caused by the certain strain which was not a general phenomenon.

在本研究中，我证实了淋球菌感染在培养细胞中引起G1期阻滞的普遍性。我通过MLST分析检查了不同菌株的G1期阻滞能力。宿主细胞使用HeLa细胞。在40个不同系统发育的菌株中，没有发现引起G1期阻滞的菌株。显著性差异轻微检查了批准的两种菌株的细胞因子产生的定量变化，但未识别出菌株之间的显著性差异。提示淋球菌感染细胞的G1期阻滞可能是由某一株淋球菌引起的，而不是一种普遍现象。

项目成果

簡易的な淋菌のスクリーニング系の検討

考虑建立一个简单的淋病奈瑟菌筛查系统

• 发表时间: 2010
• 作者: 市川潤;岡田淳志;安井孝周;廣瀬泰彦;藤井泰普;新美和寛;東端祐司;伊藤恭典;戸澤啓一;郡健二郎;志牟田健
• 通讯作者: 志牟田健

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Temporal and spatial expression patterns of Cdc25 phosphatase isoforms during early Xenopus development

非洲爪蟾早期发育过程中 Cdc25 磷酸酶亚型的时空表达模式

• 发表时间: 2011
• 期刊: International Journal of Developmental Biology (in press)
• 作者: Nakajo;N;Deno;Y;Ueno;H;Kenmochi;C;Shimuta;K;Sagata;N
• 通讯作者: N

Spread of a Chromosomal Cefixime-Resistant penA Gene among Different Neisseria gonorrhoeae Lineages

• DOI: 10.1128/aac.01010-09
• 发表时间: 2010-03-01
• 期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
• 影响因子: 4.9
• 作者: Ohnishi, Makoto;Watanabe, Yuko;Watanabe, Haruo
• 通讯作者: Watanabe, Haruo

Spreading of a chromosomal cefixime resistant penA gene among different Neisseria gonorrhoeae lineages.

染色体头孢克肟抗性 penA 基因在不同淋病奈瑟菌谱系中的传播。

• 发表时间: 2010
• 期刊: Antimicrob Agents Chemother 54(3)
• 作者: Ohnishi;M;Watanabe;Y;Ono;E;Takahashi;C;Oya;H;Kuroki;T;Shimuta;K;Okazaki;N;Nakayama;S;Watanabe;H
• 通讯作者: H