Antitumor effect of siRNA on endometrial cancer
Antitumor effect of siRNA on endometrial cancer
批准号:
21791573
负责人:
YANOKURA Megumi
金额:
$4.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
将HEC-1B细胞移植到裸小鼠体内3周后发生肿瘤。当天及之后给予药物。紫杉醇+Aurora-A siRNA治疗组小鼠的肿瘤直径与其他治疗组相比显著减小(P<0. 05)。05)。paclitaxel+Aurora-A siRNA治疗后,GFP荧光信号也明显减弱,Aurora-A siRNA可能具有增加子宫内膜肿瘤对paclitaxel治疗敏感性的潜力。
英文摘要
Tumor development occurred 3 weeks after transplantation of HEC-1B cells in nude mice. Drugs were administered on that day and thereafter. The tumor diameter significantly decreased in mice treated with paclitaxel+Aurora-A siRNA compared with the results for other treatments(P<0. 05). The GFP fluorescence signal also markedly decreased after treatment with paclitaxel+Aurora-A siRNA.Aurora-A siRNA may have the potential to increase the sensitivity of endometrial tumors to treatment with paclitaxel.
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会议论文
Reprogramming study of endometrial cancer cells for restoring fertility
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批准号:18K09272
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2018
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负责人:YANOKURA Megumi
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依托单位:
Genome-wide DNA methylation analysis in endometrial cancer
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批准号:15K10727
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2015
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负责人:YANOKURA Megumi
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依托单位:
Combinational antitumor effect of siRNA against M phase checkpoint gene and paclitaxel on growth of human endometrial cancer
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批准号:19791163
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.36万
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财政年份:2007
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负责人:YANOKURA Megumi
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依托单位:
海外基金