The Mechanisms of lymph node metastases in head and neck carcinoma

我们重点研究了头颈部恶性肿瘤患者颈部淋巴结与原发灶之间的颈部脂肪。在人颈部发现了脂肪相关的类肉瘤簇（Fat-Associated Approphoid Cluster，CCLC），并研究了其与癌症转移的相关性。放射治疗后这些细胞数量明显减少，而在患侧颈部和远处转移患者的颈部这些细胞数量明显增加。头颈部肿瘤的转移能力可能与CD 4C有关。

We focused on the neck fat locating between neck lymph nodes and the primary lesion in patients with head and neck cancer. Fat-Associated Lymphoid Cluster(FALC) was identified in human neck and investigated the relevance of cancer metastasis. These cell populations were significantly reduced by radiation therapy.On the other hand these cells were significant increased in the affected side of the neck and in patients' neck with distant metastasis. FALC might have some relationship to the metastatic ability of head and neck cancer.