The Mechanisms of lymph node metastases in head and neck carcinoma

头颈癌淋巴结转移的机制

• 批准号: 21791595
• 负责人: CHAZONO Hideaki
• 金额: $ 2.25万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791595/
• 关键词: 頭頸部癌; VEGF; 頸部脂肪組織; リンパ節転移; 脂肪関連リンパ球集積; 頸部リンパ節転移

We focused on the neck fat locating between neck lymph nodes and the primary lesion in patients with head and neck cancer. Fat-Associated Lymphoid Cluster(FALC) was identified in human neck and investigated the relevance of cancer metastasis. These cell populations were significantly reduced by radiation therapy.On the other hand these cells were significant increased in the affected side of the neck and in patients' neck with distant metastasis. FALC might have some relationship to the metastatic ability of head and neck cancer.

我们对头颈癌患者颈淋巴结与原发灶之间的颈部脂肪分布进行了研究。脂肪相关淋巴团(FALC)在人类颈部被发现，并研究了其与肿瘤转移的相关性。这些细胞群在放射治疗后显著减少。另一方面，在受影响的一侧颈部和远处转移的患者颈部，这些细胞显著增加。FALC可能与头颈癌的转移能力有一定关系。

项目成果

ヒト頸部脂肪組織における脂肪関連リンパ球集積の免疫化学染色による検討

使用免疫化学染色研究人宫颈脂肪组织中脂肪相关淋巴细胞的积累

• 发表时间: 2011
• 作者: 高安幸弘;古屋信彦;RS Zukin;茶薗英明
• 通讯作者: 茶薗英明