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A study of inner ear immune response after acoustic trauma

声损伤后内耳免疫反应的研究

基本信息

批准号：
21791602
负责人：
MIYAO Masumichi
金额：
$ 1.66万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

The aim of this study is to solve whether acoustic trauma, which activates an inner ear immune response with cytokine expression and infiltration of circulating leukocytes could augment the response to antigen. I sensitized mice to an antigen, injected it intracochlearly, through the round window membrane(RWN), and subsequently exposed the mice to noise.The immunohistochemical analysis indicates that infiltration of inflammatory cells was present in cochlea with intracochlear antigen challenge. However, noise exposure cannot activate a cochlear immune response, which in the presence of antigen. I speculate that pure tone with lower sound pressure level causes lower inner ear immune response than octave-band noise stimulation.

本研究的目的是解决声损伤是否可以增强对抗原的反应，声损伤通过细胞因子表达和循环白细胞浸润激活内耳免疫反应。本实验将抗原致敏小鼠，经圆窗膜（RWN）耳蜗内注射抗原，然后暴露于噪声中，免疫组化分析表明，耳蜗内抗原激发后，耳蜗内有炎性细胞浸润。然而，噪声暴露不能激活耳蜗免疫反应，这在抗原存在的情况下。我推测，纯音与较低的声压级，导致较低的内耳免疫反应比倍频程噪声刺激。