Elucidation of the carcinogenesis mechanism in a precancerous lesion and the extension of squamous cell carcinoma of the head and neck region

我们采用组织病理学技术，以癌前病变标本为研究对象，研究了头颈部鳞状细胞癌发生和扩散机制中的预后因素。对于喉癌前病变和舌癌前病变，抑癌基因FHIT表达降低和EGFR蛋白表达增加可作为癌变的指标。此外，对于喉癌的疾病特异性存活率，FHIT蛋白表达降低和EGFR表达增加可作为预后不良的预测指标。

We employed histopathological techniques to examine prognostic factors in the mechanism of carcinogenesis as well as extension in squamous cell carcinoma of the head and neck region, using a specimen of a precancerous lesion. For laryngeal and lingual precancerous lesions, decreased expression of cancer-restraining gene FHIT and increased expression of protein EGFR were found to be useful as indices of carcinogenesis. Also, regarding the disease-specific survival rate in laryngeal cancer, decreased expression of FHIT protein and increased expression of EGFR were useful as predictors of a poor prognosis.