The role of TRP family in Geniculate Ganglion

TRP家族在膝状神经节中的作用

• 批准号: 21791656
• 负责人: KATSURA Hirokazu
• 金额: $ 2.25万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791656/
• 关键词: 鼓索神経; 舌知覚; 膝神経節; 耳手術; 味覚障害; 鼓索神経切断モデル; 神経栄養因子; 顔面神経; 三叉神経節; モノフィラメント圧痛計; ディスククリミネーター

Patients often complain of taste disorder and tongue numbness after middle ear surgery. In the present study, postoperative trigeminal sensation of the tongue was examined by Sennes-Weinstein sensory test (SW test) and two-point discrimination tests. There were no significant differences on SW test, two point discrimination tests or EGM although the threshold of each test was elevated after surgery. The expression of TRP family in Geniculate Ganglion was no significant after cholda tympanic nerve injury. There findings suggested that injury to the chorda tympani nerve during middle ear surgery induces trigeminal disorder together with taste disorder.

患者经常抱怨中耳手术后味觉障碍和舌头麻木。在本研究中，通过Sennes-Weinstein感觉测试（SW测试）和两点辨别测试来检查术后舌三叉神经感觉。SW试验、两点辨别试验和EGM的阈值在术后均有所提高，但差异无统计学意义。TRP家族在鼓胆神经损伤后膝状神经节中的表达无明显变化。提示中耳手术中鼓索神经损伤可引起三叉神经功能紊乱及味觉障碍。