Pathology of retinitis pigmentosa detected by adaptive optics scanning laser ophthalmoscopy

我们利用自适应光学扫描激光眼底镜的高分辨率感光图像研究了视网膜色素变性的病理。视网膜色素性视网膜炎表现为异常的锥状马赛克，而正常眼均可见规则的锥形马赛克。视网膜色素变性患者视锥细胞密度较正常眼明显降低。视锥细胞密度与视功能(视力和视网膜敏感度)相关。根据这些数据，我们开发了一个评估视力预后的程序，并表明AO-SLO对评估视网膜色素变性患者的治疗效果是有用的。

We investigated the pathology of retinitis pigmentosa by high-resolution photoreceptor images using adaptive optics scanning laser ophthalmoscopy. Abnormal patterns of cone mosaic were observed in retinitis pigmentosa though regular cone mosaic was seen in all normal eyes. Cone density was significantly decreased in retinitis pigmentosa, compared with normal eyes. Cone density correlated with visual function (visual acuity and retinal sensitivity). From these data we developed a program for evaluating visual prognosis, and showed that AO-SLO is useful for evaluating the treatment effect in patients with retinitis pigmentosa.