Effect of prostaglandin analogues on contraction and degradation of collagen gel mediated by human scleral fibroblasts

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Prostaglandin analogues improve uveoscleral outflow, but its mechanism and physiology of uveoscleral outflow are still unknown. In this study, prostaglandin analogues induced collagen gel contraction mediated by human scleral fibroblasts. This action of prostaglandin analogues appeared to depend on the formation of stress fibers as well as the activation of mitogen-activated protein kinase, focal adhesion kinase, Rho-associated kinase in human scleral fibroblasts. Prostaglandin analogues might therefore influence scleral structure by affecting the contractility of scleral fibroblasts, resulting in improvement of uveoscleral outflow.