Age-dependent profiles of inflammatory cells recruited to skin wounds of fetal mouse

哺乳动物胎儿的皮肤伤口可以再生，不会留下明显的疤痕，但之后就不可能了。炎症反应的强度似乎是强调这一现象的机制之一。研究发现，从妊娠第17天开始，大量中性粒细胞开始被招募到伤口，这与皮肤结构和皮肤附属物的再生能力相吻合。向早期胎儿皮肤伤口注射中性粒细胞会延迟愈合。中性粒细胞弹性蛋白酶可能是抑制小鼠皮肤早期创面愈合的因素之一。

Skin wounds in mammalian fetuses regenerate and do not leave visible scar, but afterwards it is no longer possible. The intensity of inflammatory response seems to be one of the mechanisms underlining this phenomenon. Investigating the profiles of inflammatory cells recruited to fetal wounds revealed that from day 17 of gestation lots of neutrophils started to be recruited to the wounds, which coincided with the ability to regenerate dermal structures and skin appendages. And injecting neutrophils into the skin wounds of early-stage fetuses delayed the healing. Neutrophil elastase seemed to be one of the factors that inhibit early wound healing of mouse skin.