Drugs improve mouse cognitive function by increasing the production of insulin-like growth factor-I

胰岛素样生长因子- i （IGF-I）对认知功能有有益作用。由于刺激感觉神经元通过释放小鼠大脑中的降钙素基因相关肽（CGRP）诱导IGF-I的产生，我们假设多奈哌齐除了对乙酰胆碱酯酶有抑制作用外，还可能对感觉神经元有刺激作用，从而通过增加海马中IGF-I的产生促进血管生成和神经发生。为了验证这种可能性，我们分析了两种选择性乙酰胆碱酯酶抑制剂（多奈哌齐和他克林）对WT小鼠、CGRP敲除[CGRP(-/-)]小鼠和新生儿给药辣椒素导致的功能性感觉神经丧失的WT小鼠海马IGF-I产生和认知功能的影响。

Insulin-like growth factor-I(IGF-I) exerts beneficial effects on cognitive function. Because stimulation of sensory neurons induces IGF-I production by releasing calcitonin gene-related peptide(CGRP) in the mouse brain, we hypothesized that donepezil may have a stimulatory effect on sensory neurons in addition to an inhibitory effect on acetylcholinesterase, thereby promoting angiogesis and neurogenesis through an increase in IGF-I production in the hippocampus. To examine this possibility, we analyzed the effects of two selective acetylcholinesterase inhibitors(donepezil and tacrine) on hippocampal IGF-I production and cognitive function in WT mice, CGRP-knockout[CGRP(-/-)] mice, and WT mice with functional sensory denervation caused by neonatal administration of capsaicin.