cytological evaluation on different effect of parathyroid hormone (PTH) in osteoblasts and preosteoblasts

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PTH administration led to significant increases in the pre-osteoblastic proliferation in both the wild-type and c-fos^<-/-> mice. The pre-osteoblasts present on the bone surfaces did not seem to be actively producing bone matrix in c-fos^<-/-> mice. We concluded that the absence of osteoclasts might hinder PTH-driven bone anabolism and that osteoclastic presence may be necessary for full osteoblastic differentiation and enhanced bone formation after the intermittent PTH administration.