Developmental mechanisms regulating tooth succession and accession in the house shrew (Suncus murinus)

调节家鼩（Suncus murinus）牙齿继承和加入的发育机制

• 批准号: 21791794
• 负责人: YAMANAKA Atsushi
• 金额: $ 2.83万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791794/
• 关键词: 歯の発生; 歯の交換; 二生歯性; 乳歯; 永久歯; Shh; スンクス; 歯の代生; 歯の加生; 実験動物スンクス; 代生; 加生; Shn

The diphyodont tooth replacement in mammals is characterized by a single replacement of a deciduous dentition by a permanent dentition. Because the mouse never replaces its teeth, this study used the house shrew, Suncus murinus, as a model to investigate the control of the diphyodont replacement by successions and accessions of teeth. The developmental sequence of tooth germs in the house shrew indicates that two adjacent tooth germs do not develop simultaneously, but with a constant time lag. We suggest that this mode of tooth succession and accession can be explained by a sequential inhibitory cascade model in which the timing of initiation and the spacing of tooth development are determined by the inhibition from developmentally preceding adjacent tooth germs.

哺乳动物的双齿型牙齿替换的特征是乳牙列被恒牙列单次替换。由于小鼠从不更换牙齿，因此本研究以家鼩（Suncus murinus）为模型，探讨牙齿的继承和加入对双齿替换的控制。齿胚的发育顺序表明，两个相邻的齿胚不是同时发育的，而是有一个恒定的时间差。我们认为，这种模式的牙齿继承和加入可以解释由一个顺序的抑制级联模型，其中启动的时间和牙齿发育的间隔是由抑制从发育前相邻的牙胚。

项目成果

Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus)

家鼩（Suncus murinus）上颌乳牙和恒牙的发育

• 发表时间: 2010
• 期刊: Archives of Oral Biology 55
• 作者: Yamanaka A;Yasui K;Sonomura T;Iwai H;Uemura M
• 通讯作者: Uemura M

The house shrew, Suncus murinus, as a model organism to investigate mammalian basal condition of tooth development.

家鼩（Suncus murinus）作为研究哺乳动物牙齿发育基础条件的模式生物。

• 发表时间: 2010
• 期刊: Journal of Oral Biosciences
• 影响因子: 2.4
• 作者: Yamanaka A;Uemura M
• 通讯作者: Uemura M

Development of deciduous and permanent dentitions in the upperjaw of the house shrew (Suncus murinus).

家鼩（Suncus murinus）上颌乳牙和恒牙的发育。

• 发表时间: 2010
• 期刊: Arch Oral Biol 55
• 作者: Yamanaka A;Yasui K;Sonomura T;Iwai H;Uemura M.
• 通讯作者: Uemura M.

Patterning of the heterodont dentitionin the house shrew (Suncus murinus).

家鼩（Suncus murinus）异齿牙列的模式。

• 发表时间: 2010
• 作者: Yamanaka A;Yasui K;Uemura M.
• 通讯作者: Uemura M.

ジャコウネズミの歯列形成過程における歯胚の発生順序

果子狸牙列形成过程中牙胚的发育顺序

• 发表时间: 2009
• 作者: 山中淳之;薗村貴弘;岩井治樹;植村正憲
• 通讯作者: 植村正憲