Relationship between transcriptional activity and structure of tooth specific transcription factor Sp6 and identification of its interaction molecules

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Through the generation of SP6 inducible system, we found that SP6 is the short lived protein and degrades via ubiquitin-independent proteasome system. We further established inducible SP6 expression system and identified some candidate genes of SP6 target by microarray analysis. Furthermore, it is suggested that the full length of SP6 and its structure may be important to regulate the subcellular localization and transcriptional activity of SP6.