Elucidation of regulatory mechanism of bone metabolism by Wnts secreted from osteoclasts.

骨通过破骨细胞骨吸收和成骨细胞骨形成进行重塑。我假设一些wnt参与了成骨细胞和破骨细胞之间的偶联。首先，我试图证明破骨细胞分泌的Wnt刺激成骨细胞的骨形成活性。但这次审判是错误的。其次，分析小鼠胫骨中Wnt相关基因的表达水平。我发现一些Wnt相关基因的表达水平是随年龄变化的。

Bone is remodeled by osteoclastic bone resorption and osteoblastic bone formation. I hypothesized that some Wnts were involved in coupling between osteoblasts and osteoclasts. At first, I tried to demonstrate an Wnt secreted from osteoclasts stimulate bone formation activity of osteoblasts. But this trial was false. Second, I analyzed expression level of Wnt related genes in tibia from mice. I revealed that expression level of some Wnt related genes were changed age-dependently.