A research and development of novel low-cytotoxic oral self-care methods for the patients who use denture adhesives.

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We first analyzed antimicrobial activity of ten kinds of commercial denture cleaner against Candida albicans by disk method. We examined eight kinds of home-care cleaners and two kinds of professional cleaners in this experimentation. Antimicrobial activity of every home-care cleaner was effective enough for clinical usage although it was lower than that of professional cleaners.Moreover, we investigate removal activities of cream-type dental adhesives in five kinds of home care cleaners by soaping method. Removal effect in almost all of the cleaning agents was larger than purified water when soaking it for more than eighteen hours. However, we clinically use denture cleaner solution for less than twelve hours, so further studies are needed for the development of new denture cleaner which could remove denture adhesive more effectively.