The analysis of multipotential immune cells induced in oral cancer patients for development of novel immunotherapy

我们研究了注射可移植口腔鳞状细胞癌后在荷瘤小鼠体内诱导的髓源性抑制细胞，并阐明了GM-CSF是维持这些细胞所必需的。但是，不同于用小鼠口腔癌细胞株产生GM-CSF的模型，口腔癌患者体内这些细胞的数量存在差异，这可能取决于人类口腔癌产生的GM-CSF的数量，因为GM-CSF的产生存在个体差异。目前正在分析这些细胞与GM-CSF产生的关系，同时分析口腔癌患者肿瘤细胞上B7-H3的表达水平。

We investigated Myeloid Derived Suppressor Cells induced in tumor-bearing mice after injection with transplantable oral squamous cell carcinoma, and clarified that GM-CSF is needed to maintain these cells. But, there is difference in quantity of these cells among oral cancer patients unlike mouse model using murine oral cancer cell line producing GM-CSF, which might be depending on quantity of GM-CSF produced by human oral cancer, because there is difference in GM-CSF production individually. The analysis of the relationship between these cells and GM-CSF production is currently under investigation, concomitantly with the analysis of expression levels of B7-H3 on tumor cells in oral cancer patients.