Clarification of Novel Metastatic mechanism in Oral Squamous Cell Carcinoma

口腔鳞状细胞癌新转移机制的阐明

• 批准号: 21792033
• 负责人: ONDA Takeshi
• 金额: $ 1.58万
• 依托单位: Tokyo Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792033/
• 关键词: 扁平上皮癌; プロテオミクス; 癌遺伝子; 癌抑制遺伝子; 口腔扁平上皮癌; 転移関連遺伝子; Spleen tyrosine kinase; zinc finger DHHC-type containing 14

The aim of this study was to identify novel metastasis-associated gene of oral squamous cell carcinoma by using DNA microarray on which all human genes are carried in order to make it possible to diagnose metastasis as well as to evaluate grade of tumor. Based on a global gene expression analysis on oral tissue, oral squamous cell carcinoma tissue and lymph node metastasis tissue, 75 of candidate genes including zinc finger DHHC-type containing 14(ZDHHC14) and Spleen tyrosine kinase(SYK) have been listed up. It has suggested a possible existence of more than 50 of genes with impaired expression, which are commonly recognized in each case, at least in oral squamous cell carcinoma, if not in all cases.

本研究的目的是利用携带所有人类基因的DNA微阵列技术筛选口腔鳞状细胞癌转移相关的新基因，为口腔鳞状细胞癌转移的诊断和肿瘤分级提供依据。通过对口腔组织、口腔鳞状细胞癌组织和淋巴结转移组织的基因表达谱分析，筛选出75个候选基因，其中包括锌指DHHC型14（ZDHHC 14）和脾酪氨酸激酶（SYK）。这表明可能存在超过50个表达受损的基因，这些基因在每种情况下都是公认的，至少在口腔鳞状细胞癌中，如果不是在所有情况下。

项目成果

Aberrant expression of the ZDHHC14 gene in squamous cell carcinoma of the human tongue

• DOI: 10.1016/j.ajoms.2010.09.001
• 发表时间: 2010-10
• 期刊: Asian Journal of Oral and Maxillofacial Surgery
• 作者: Takeshi Onda;N. Yamamoto;Tsukasa Kuroiwa;A. Katakura;N. Takano;T. Shibahara