Clarification of Novel Metastatic mechanism in Oral Squamous Cell Carcinoma

本研究的目的是利用携带所有人类基因的DNA微阵列技术，鉴定新的口腔鳞状细胞癌转移相关基因，从而为口腔鳞状细胞癌的转移诊断和肿瘤分级提供可能。通过对口腔组织、口腔鳞状细胞癌组织和淋巴结转移组织的全局基因表达分析，列出了锌指DHHC-type containing 14（ZDHHC14）和脾酪氨酸激酶（SYK）等75个候选基因。研究表明，可能存在超过50种表达受损的基因，这些基因通常在每种情况下都被发现，至少在口腔鳞状细胞癌中，如果不是在所有情况下。

The aim of this study was to identify novel metastasis-associated gene of oral squamous cell carcinoma by using DNA microarray on which all human genes are carried in order to make it possible to diagnose metastasis as well as to evaluate grade of tumor. Based on a global gene expression analysis on oral tissue, oral squamous cell carcinoma tissue and lymph node metastasis tissue, 75 of candidate genes including zinc finger DHHC-type containing 14(ZDHHC14) and Spleen tyrosine kinase(SYK) have been listed up. It has suggested a possible existence of more than 50 of genes with impaired expression, which are commonly recognized in each case, at least in oral squamous cell carcinoma, if not in all cases.