Elucidation of the Mechanism of Odontblast Differentiation by Bone Morphogenetic Factor and Application to Regeneration

骨形态发生因子阐明成牙本质细胞分化机制及其在再生中的应用

• 批准号: 21792053
• 负责人: MARUYA Yuriko
• 金额: $ 2.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792053/
• 关键词: 小児歯科学; 歯髄幹細胞; GDF-5; 歯の再生

Growth/Differentiation Factor-5 (GDF-5) is a member of the bone morphogenetic protein and promotes formation of bones and cartilages. It has been reported that GDF-5 gene is expressed in oral region. However, the roles of GDF-5 in the differentiation of dental pulp cells are unknown. Thus, we investigated the effect of GDF-5 on the differentiation of dental pulp stem cell.GDF-5 promoted production of molecules characteristic for odontoblastic phenotype. These findings suggested that GDF-5 promotes differentiation of dental pulp stem cell to odontblast.

生长/分化因子-5（GDF-5）是骨形态发生蛋白的一员，促进骨和软骨的形成。已有报道GDF-5基因在口腔区域表达。然而，GDF-5在牙髓细胞分化中的作用尚不清楚。因此，我们研究了GDF-5对牙髓干细胞分化的影响，GDF-5促进了成牙本质细胞表型特征分子的产生。这些结果表明GDF-5促进牙髓干细胞向成牙本质细胞分化。

项目成果

唇顎口蓋裂児の齲蝕罹患に関する実態調査

唇腭裂儿童龋齿发病率调查

• 发表时间: 2010
• 期刊: 小児歯科学雑誌 48
• 作者: 高崎千尋;大島昇平;岡田理恵子;八若保孝;松野美乃;丸谷由里子
• 通讯作者: 丸谷由里子

Clinical Evaluation of One-step Adhesive System

一步式粘合系统的临床评价

• 发表时间: 2010
• 作者: 高崎千尋;大島昇平;岡田理恵子;八若保孝;松野美乃;丸谷由里子;Yuriko Maruya
• 通讯作者: Yuriko Maruya