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Effect of liquid diet on purkinje cells in cerebellum

流质饮食对小脑浦肯野细胞的影响

基本信息

批准号：
21792062
负责人：
YABUSHITA Tadachika
金额：
$ 2.66万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2010
项目状态：
已结题

项目摘要

Recently, it has been shown that prolonged feeding on liquid diet after being weaned impedes functional development and leads to immature mastication in growing rats. Since jaw muscle spindles play an important role in the control of jaw movements during normal masticatory function, in this study we investigated the effect of prolonged feeding on liquid diet after being weaned on the functional development of jaw-closing muscle spindles in growing rats. Soon after weaning, 40 female Wistar rats were divided into two equal groups. The control group fed on solid diet and the experimental group fed on liquid diet. At 5, 7, 9 and 11 weeks, the rats were anesthetized and the response of the masseter muscle spindles to ramp-and-hold jaw stretches were recorded from the mesencephalic trigeminal nucleus. In the experimental groups, both the dynamic and the static indices were significantly lower than those of the control groups at the age of 5, 7, 9 and 11 weeks old. There was no significant change within the same group during the experimental period in both indices. These results suggest that long-term masticatory functional change due to liquid diet feeding may impede maturation of the functional properties of jaw-closing muscle spindles, leading to immature mastication in growing rats.

最近，研究表明，断奶后长时间喂流质食物会阻碍功能发育，导致生长期大鼠咀嚼功能不成熟。由于下颌肌梭在正常咀嚼功能的下颌运动控制中起着重要的作用，在本研究中，我们研究了断奶后长时间喂食流质食物对生长期大鼠下颌闭合肌梭功能发育的影响。断乳后不久，40只雌性Wistar大鼠分为两组。对照组喂固体饲料，实验组喂流质饲料。在第5、7、9和11周，麻醉大鼠，从三叉神经中脑核记录咬肌肌梭对斜举和保持下颌伸展的反应。实验组在5、7、9、11周龄时的动态和静态指标均显著低于对照组。在实验期间，同一组内两项指标均无显著变化。这些结果表明，长期咀嚼功能的变化，由于液体饮食喂养可能会阻碍成熟的功能特性的下颌闭合肌梭，导致咀嚼发育不成熟的大鼠。