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神経筋系からみた生活習慣病に対する運動およびその対象者に関する運動生理学的研究

神经肌肉系统视角下运动与生活方式疾病受试者的生理学研究

基本信息

批准号：
10J01944
负责人：
渡邊航平
金额：
$ 1.22万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

高齢者や生活習慣病患者における運動の実施が広く推奨されている.これらの人々における運動時の生理応答や運動機能を十分に理解し,運動生理学的なエビデンスに基づいた運動処方を提案することは,我々の研究領域における重要な課題の1つであると考えられる.本研究は,高齢者および生活習慣病の代表格である2型糖尿病の患者において,運動時の骨格筋の収縮を制御するシステム,すなわち神経筋系の機能特性を明らかにすることを目的とした.この研究では,従来は侵襲的な手法(針筋電図など)によってのみ得られてきた詳細な神経筋活動に関する情報を非侵襲的に得ることができる「多チャンネル表面筋電図法」という新たな手法を用いて実験を行った.本年度の研究成果として,高齢者では若齢者とは異なる方略によって骨格筋の活動を制御していること(Watanabe et al.J Electromyogr Kinesiol,2012a),2型糖尿病患者では持続的な運動を行っている際に筋内の限られた同じ部分が活動し続けること(Watanabe et al.Diabetes Res Clin Pract,in press)を査読付き国際誌に原著論文(筆頭著者)として報告した.これらの研究成果は,高齢者の神経筋機能を評価する新たな手法の開発や2型糖尿病患者で見られる運動耐容能の低下の原因の解明につながると考えられる.また,骨格筋の制御システムを理解するための基礎的な研究として,大腿四頭筋を構成する4つの筋は関節角度によってそれぞれ異なる筋活動レベルとなること(Watanabe et al.Scand J Med Sci Sports,2012),1つの筋であっても部位によって異なる役割を担っていること(Watanabe et al.J Electromyogr Kinesiol, 2012b)を査読付き国際誌に原著論文(筆頭著者)として発表した.これらの研究成果の発表に加えて,海外渡航制度を利用してイタリア・トリノ工科大学にて共同研究のため約3ヶ月間滞在し,世界でもこの研究機関でしか扱っていない特殊な解析プログラムを用いて,昨年度日本国内で取得したデータの詳細な解析を行った.

People with high levels of health care are suffering from illness. people who are sick and sick are not allowed to do so. The physiological response of people during exercise is very understandable, and the basic principles of exercise physiology, the proposals of the parties involved in the exercise are not fully understood, and we are involved in the study of important issues in the field of research. In this study, the patients with advanced diabetes mellitus were diagnosed as patients with type 2 diabetes. in this study, the patients with type 2 diabetes were treated with skeletal tendons during exercise, and the mechanical characteristics of the patients with type 2 diabetes were demonstrated by mechanical properties. After a lot of research, the method of intrusive treatment (steel bar electricity) has been used, and the new technique has been used in non-intrusive practice, such as the use of multi-agent, the method of surface reinforcement computer, and the new method of communication. The results of this year's research have been published, and high achievers are interested in the strategy for the preparation and control of exercise training (Watanabe et al.J Electromyogr Kinesiol,2012a). Patients with type 2 diabetes are involved in the exercise control exercise (Watanabe et al.Diabetes Res Clin Pract). In press) to pay for the report of the original article (author of the book) of International. According to the results of the research, people with high levels of mental health can use new techniques to explore the causes of low exercise tolerance in patients with type 2 diabetes. The four tendons of the thigh are divided into four tendons, the four tendons of the thigh are divided into four tendons, the four tendons of the thighs are divided into four tendons, the four tendons of the thighs are divided into four tendons, the four tendons of the thighs are divided into four tendons, the four tendons of the thighs are divided into four tendons, the four tendons of the thighs are divided into four tendons, the four tendons of the thighs are divided into four tendons, the four tendons of the thighs are divided into four tendons, the four tendons of the thighs are divided into four tendons, the four tendons of the thighs, the tend 2012b) please pay for the original text of the International Academy of Sciences (author of the book). There has been an increase in the list of research results, and the overseas voyage system has been stagnant for about 3 months in the joint research program of the University of Engineering and Technology. The world's research institutions have been holding up for about 3 months, and the analysis of special equipment has been completed in Japan yesterday.