Analysis of molecular link between Alzheimer' s disease and diabetes mellitus

炎症可能参与了阿尔茨海默病、S病与糖尿病之间的分子联系。我们发现，外周注射脂多糖后，阿尔茨海默病APP-TG组小鼠脑炎性细胞因子(IL-6)水平的增加明显高于WT组小鼠。APP-TG小鼠在外周诱发炎症期间血脑屏障(BBB)变得更具通透性，这表明在这种AD动物模型中，BBB对炎症的易感性增加。这些发现可能支持炎症参与了阿尔茨海默病、S病和糖尿病之间的分子联系的假设。

Inflammation might be involved in the molecular link between Alzheimer' s disease and diabetes mellitus. We showed that the increase in brain inflammatory cytokine(interleukin-6) level was significantly higher in Alzheimer APP-Tg than in WT mice after peripheral LPS injection. Blood-brain barrier(BBB) became more permeable in APP-Tg mice during peripherally evoked inflammation, suggesting the increased vulnerability of BBB to inflammation in this animal model of AD. These findings might support the hypothesis that inflammation is involved in the molecular link between Alzheimer' s disease and diabetes mellitus.