Studies on resin allergy using murine models

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At the start of the project, we were thinking that we had succeed in establishing the murine model of resin allergy by experiments using a preparation of resin monomer methyl methacrylate(MMA)that is clinically used in dentistry. However, in later experiments using a reagent grade of MMA, we could not reproduce it, leading us to speculate that"LM might promote allergies to allergens other than LM". Metal allergies are dentistry-associated allergies with a high incidence. Thus, we examined the adjuvant effect of RM on Ni-allergy. We found that both MMA and 2-hydroxyethyl methacrylate(HEMA)are inflammatory and promote Ni allergy in mice. Various microbial substances and nitrogen-containing bisphosphonates(NBPs, anti-bone-resorptive drugs)also promoted Ni allergy. These findings suggest that inflammatory chemicals, as well as oral bacteria, may promote metal allergies as an immunological adjuvant.