Microscopic analysis based on the quantitative behavioral tests in rodents for identification of the molecular target of developmental neurotoxicity

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The aim of this study is to develop the microscopic analysis methodology, and identify the molecular marker for developmental neurotoxicity of environmental chemicals. We found that perinatal exposure to a low dose of dioxin induces abnormal behaviors, including behavioral inflexibility, compulsive repetitive behavior, and low social dominance in mice. Immuhohistochemical analysis validated that hypoactivation of the medial prefrontal cortex (mPFC) and hyperactivation of the amygdala are the potential biological basis for these behavioral abnormalities.