Mechanism underlying the glucocorticoid-decreased function of neurotrophic factor in depression.

糖皮质激素（应激激素）暴露后，培养的皮质神经元中bdnf依赖性突触成熟减少。我们发现，对bdnf介导的突触蛋白表达很重要的shp2-TrkB相互作用也减少了。在体内模型中，我们检测了约束应激后前脑bdnf相关细胞内信号的可能变化。我们发现抑制手术后GR明显下调，并证实bdnf刺激的神经递质释放减少。

Following glucocorticoid(stress hormone) exposure, BDNF-dependent synaptic maturation was decreased in cultured cortical neurons. We found that shp2-TrkB interaction, which is important for BDNF-mediated synaptic protein expression, was also reduced. In vivo models, we examined possible change of BDNF-related intracellular signaling in forebrain after restraint stress. We found that significant GR downregulation after restraint operation and confirmed a decrease in BDNF-stimulated neurotransmitter release.