A new therapeutic strategy for tumor induced bone destruction targeting FAK

针对FAK的肿瘤诱导骨破坏的新治疗策略

• 批准号: 21689050
• 负责人: SHIMO Tsuyoshi
• 金额: $ 8.49万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689050/
• 关键词: FAK; 破骨細胞; 癌骨浸潤; 口腔扁平上皮癌; 血管新生; 癌骨破壊

Focal adhesion kinase(FAK) is a 125-kDa non-receptor type tyrosine kinase that localizes to focal adhesions. FAK overexpression is frequently found in invasive and metastatic cancers, but its role in osteolytic metastasis is not well understood. In this study, we have analyzed anti-tumor effects of the FAK against bone metastasis in cancer, we found that FAK was critically involved in osteolytic metastasis and activated in tumors, pre-osteoclasts, and mature osteoclasts. These results suggest that FAK can be effective target for the treatment of cancer induced bone metastasis.

局灶黏附激酶（FAK）是一种125 kda的非受体型酪氨酸激酶，定位于局灶黏附。FAK过表达常见于侵袭性和转移性癌症，但其在溶骨转移中的作用尚不清楚。在本研究中，我们分析了FAK对肿瘤骨转移的抗肿瘤作用，我们发现FAK在肿瘤、破骨前细胞和成熟破骨细胞中具有重要的参与和激活作用。提示FAK可作为治疗肿瘤骨转移的有效靶点。

项目成果

Effect of a novel FAK inhibitor TAE226 on the breast cancer associated with bone metastasis

新型FAK抑制剂TAE226对乳腺癌骨转移的影响

• 发表时间: 2011
• 期刊: Experimental Cell Research
• 影响因子: 3.7
• 作者: Naito Kurio;Tsuyoshi Shimo;Takuya Fukazawa;Munenori Takaoka;Tatsuo Okui;Nur Mohammad Monsur Hassan;Tatsuki Honami;Shinji Hatakeyama;Masahiko Ikeda;Yoshio Naomoto;Akira Sasaki
• 通讯作者: Akira Sasaki

Focal adhesion kinaseの口腔扁平上皮癌血管新生における役割

粘着斑激酶在口腔鳞状细胞癌血管生成中的作用

• 发表时间: 2011
• 作者: Nemoto H;Nakano K;Masuda K;Wada K;Ardin AC;Nomura R;Ooshima T;Hiroki Morizumi;栗尾奈愛
• 通讯作者: 栗尾奈愛

Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma

• DOI: 10.1016/j.oraloncology.2012.05.019
• 发表时间: 2012-11-01
• 期刊: ORAL ONCOLOGY
• 影响因子: 4.8
• 作者: Kurio, Naito;Shimo, Tsuyoshi;Sasaki, Akira
• 通讯作者: Sasaki, Akira

A Novel Focal Adhesion Kinase Inhibitor TAE226 Suppresses Parathyroid Related Protein Induced Hypercalcemia and Reduced Osteoclast Activation

新型粘着斑激酶抑制剂 TAE226 抑制甲状旁腺相关蛋白诱导的高钙血症并减少破骨细胞活化

• 发表时间: 2010
• 作者: Naito Kurio;Tsuyoshi Shimo;Nur Mohammad Monsur Hassan;Tatsuo Okui;Tatsuki Honami;Shinji Hatakeyama;Munenori Takaoka;Yoshio Naomoto;Akira Sasaki
• 通讯作者: Akira Sasaki

Induction of MMP-13 Expression in Bone-metastasizing Cancer Cells by Type I Collagen through Integrinα1β1 andα2β1-p38 MAPK Signaling

I 型胶原通过整合素α1β1 和α2β1-p38 MAPK 信号传导诱导骨转移癌细胞中 MMP-13 的表达

• 发表时间: 2011
• 期刊: Anticancer Research
• 影响因子: 2
• 作者: Soichiro Ibaragi;Tsuyoshi Shimo;Masahiro Iwamoto;Nur Mohammad Monsur Hassan;Sachiko Isowa;Naito Kurio;Hiroki Mandai;Shinichi Kodama;Akira Sasaki.
• 通讯作者: Akira Sasaki.