Regulation of differentiation/maturation of neocortical neurons after radial migration

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Neural precursor cells in the neocortex give rise to distinct subtypes of six-layered neurons, which posses different characteristics. It has been thought that subtype specification of these neurons occurs when the precursor cells undergo final mitosis. However, our group recently found that subtype specification of layer IV neurons occurred at later stages, when the neurons already finished their radial migration. In this study, I tried to explore the mechanisms of subtype specification of layer IV neurons after neuronal migration and found that thalamocortical axons played an important role in this process.