Does an activation of RAR improve Alzheimer disease by the expression of transthyretin?

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I investigate the mechanism of anti-Alzheimer effect of retinoic acid receptor activation focused on the transthyretin (TTR), by using senescence accelerated (SAMP8) mice. As the results, the activation of RAR improves the memory function of SAMP8. However, the protein expression of TTR was not shown. On the other hands, Adam10 protein, which has α-secretase activity and correlates with neurogenesis, is significantly recovered by the RAR activation. The effect of Adam10-derivedα-secretase activity for amyloid beta is not clear because SAMP8 mice did not show the deposit of amyloid beta in this study. However, the expression of Hes5, which associates with neurogenesis, showed the significant increase in RAR-activated SAMP8 mice. Besides that, the expression of Adam10 and Hes5 are significantly correlated. The results in this study suggest that the RAR activation is improved memory function of SAMP8 by the recovery of Adam10 expression.