Analysis of molecular mechanism of neuron-glia interaction in long-term memory formation

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Recent studies suggest that glias are implicated in synapse formation and plasticity through neuron-glia interaction. However, how they contribute to the long-lasting memory is not clear. Previously we found that training-dependent increase in Drosophila Klingon (Klg), a homophilic cell adhesion molecule, is required for long-term memory (LTM) formation. In this study we purposed to elucidate the function of neuron-glia interaction in LTM formation through the functional analysis of Klg. Klg protein was expressed in both neurons and glia, and a training-dependent increase in neuron-glia interactions mediated by Klg was required to form LTM. Furthermore, we identified that neuron-glia interactions via Klg modulate glial-gene expression required for LTM formation.