Blood flow simulation integrated with ultrasonic measurement of small animals

为了获得准确、详细的小动物血流动力学信息，进行了超声-测量-集成(UMI)模拟的可行性研究，即根据超声测量和数值模拟之间的误差在控制方程中添加反馈信号。用PVA凝胶制成超声图像类似于小动物动脉的流道。通过实验测量小鼠颈动脉和人手指动脉的血流通道和实际血流，提高了UMI模拟的计算精度，表明了活体测量的可行性。

Feasibility study of ultrasonic-measurement-integrated (UMI) simulation, in which feedback signals are added to the governing equations based on errors between ultrasonic measurement and numerical simulation, was performed to obtain accurate and detailed information of hemodynamics in small animals. Flow channel whose ultrasound image was similar to that of an artery in a small animal was made from PVA gel. By experiments measuring flows in flow channels and real blood flows in mouse carotid artery or in human finger artery, the computational accuracy of UMI simulation was improved, showing the feasibility of in vivo measurement.