Blood flow simulation integrated with ultrasonic measurement of small animals

为获得小动物血流动力学的准确、详细信息，对超声测量集成（UMI）仿真的可行性进行了研究，即根据超声测量与数值模拟之间的误差，在控制方程中加入反馈信号。用聚乙烯醇（PVA）凝胶制成超声图像与小动物动脉相似的流动通道。通过测量流道内的流动和小鼠颈动脉和人手指动脉内真实的血流，提高了UMI模拟的计算精度，验证了在体测量的可行性。

Feasibility study of ultrasonic-measurement-integrated (UMI) simulation, in which feedback signals are added to the governing equations based on errors between ultrasonic measurement and numerical simulation, was performed to obtain accurate and detailed information of hemodynamics in small animals. Flow channel whose ultrasound image was similar to that of an artery in a small animal was made from PVA gel. By experiments measuring flows in flow channels and real blood flows in mouse carotid artery or in human finger artery, the computational accuracy of UMI simulation was improved, showing the feasibility of in vivo measurement.