Development of Clathrate-type single-cell array chip using thermoresponsive polymer

我们通过提供具有光交联和热交联能力的温敏聚合物来开发生物抗蚀剂。生物抗蚀剂可用于通过光刻和热纳米压印的微制造。而微小的生物抗蚀剂图案可以通过改变温度而可逆地改变。此外，我们开发了一种笼形单细胞阵列芯片，它由许多阵列的生物抗蚀剂孔图案，小物体，如单细胞可以捕获和释放。

We developed Bio-resist by providing thermoresponsive polymer with photocrosslinking and thermal cross-linking capabilities. The Bio-resist can be used for micro fabrication by photolithography and thermal-nanoimprint. And small Bio-resist patterns could be changed reversibly by changing temperature. Moreover, we developed a clathrate-type single-cell array chip which consists of many arrays of Bio-resist hole patterns where small objects such as single-cells can be captured and released.