Basic study of new minimally invasive cancer treatment method of by particle sensitization method.

粒子致敏法肿瘤微创治疗新方法的基础研究。

• 批准号: 21700514
• 负责人: SHIMADA Hirofumi
• 金额: $ 2万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700514/
• 关键词: 医療・福祉; 癌; 重粒子線治療; 光線力学的療法; 放射線化学; 蛍光プローブ; 光線力学療法

It was able to be confirmed that fluorescence was measured by optical excitation of the irradiation sample after it irradiated it from the upper side while stirring various samples, and the generation of active oxygen species was promoted by the presence of the medicine for PDT. The cytotoxicity reaction was able to be found the survival rate of the cell decreasing compared with the control group that had not added the machine screw dyne, and improving by irradiating and using together with the photosensitization medicine when X rays were irradiated by using lung cancer epithelial cell (A-549) and the machine screw dyne (5 Gy).

可以证实，在辐射样品从上侧辐射后，通过搅拌各种样品辐射出荧光来测量荧光，并通过使用PDT的药物来促进活性氧的产生。与未添加机器螺钉动力的对照组相比，细胞毒性反应可以发现细胞的存活率降低，并通过使用肺癌上皮细胞（A-549）和机器螺钉Dyne（5 Gy）来辐射X射线时，通过照射并与光敏药物一起改善。