Development of ultrasound molecular imaging with targeted-microbubbles

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The feasibility of preparation method of antibody-carrying microbubbles based on the clinically available ultrasound contrast agent, Sonazoid was examined. By utilizing the Annexin V and avidin-biotin complex formation, the attachment of IgG antibodies onto the surface of Sonazoid bubbles was feasible. Although the further study should be required, the molecular targeted-bubbles based on Sonazoid might be applicable to the clinical settings for ultrasound molecular imaging in the near future.