Molecular biological analysis of microwave irradiation under a non-thermal condition

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I investigated damage and differentiation of PC12 cells and fibroblast cells caused by microwave irradiation. The frequency of neurite outgrowth induced by 2.45 GHz (200 W) of microwave irradiation was approximately 10-fold greater than that in non-irradiated control cells. Microwave treatment of PC12m3 cells resulted in an increased level of p38 MAPK activity. On the other hand, microwave irradiation had a toxic effect on PC12 parent cells with normal levels of p38 MAPK activity induced by various stimuli. These findings indicate that p38 MAPK is responsible for the survival of PC12m3 cells and might induce neurite outgrowth via a CREB signaling pathway in PC12m3 cells subjected to microwave irradiation.