Influence of PGC-1αand nuclear receptor gene polymorphisms on endurance performance and muscular mitochondria

本研究探讨PGC-1和核受体基因多态性是否影响耐力表现和肌肉线粒体含量。pgc -1α基因多态性的Gly/Gly+Gly/Ser和PPARδ基因T294C多态性的T/T+T/C分别显著高于Ser/Ser和C/C。在运动训练研究中，Gly/Gly组LDL胆固醇的降低幅度大于Gly/Ser组和Ser/Ser组。乳酸门槛强度的提高在T/T下高于T/C和C/C。然而，这些多态性不受肌肉线粒体含量的影响。

Present study investigate whether the gene polymorphisms of PGC-1 and nuclear receptor affects endurance performance and muscular mitochondrial content. The Gly/Gly+Gly/Ser of PGC-1αgene polymorphism, and T/T+T/C of PPARδ gene T294C polymorphism, are significantly higher endurance performance than that of Ser/Ser and C/C, respectively. In exercise training study, the decrease of LDL cholesterol is greater in Gly/Gly than the Gly/Ser, and Ser/Ser. The improvement of lactate threshold intensity is higher in T/T than the T/C, and C/C.However, those polymorphisms are not affected in muscular mitochondrial content.