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Establishment of molecular mechanism of exercise motivation using a novel rat-strain featured by high levels of wheel-running activity

利用高轮跑活动水平的新型大鼠品系建立运动动机的分子机制

基本信息

批准号：
21700696
负责人：
MORISHIMA Masaki
金额：
$ 2.25万
依托单位：
Oita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

We established a novel rat strain featured by high levels of voluntary wheel-running, which is called SPORTS(Spontaneously-Running Tokushima-Shikoku) rat. The aim of this study was to investigate the effect of high-or low-intensities in voluntary exercise on sympathetic and vagal controls of heart at sedentary and during wheel-running exercise by use of SPORTS rats. At 15 weeks of age, each rat was moved to a new cage with or without an exercise wheel, and sorted into four groups ; 1) SPORTS rat with an exercise wheel(running), 2) SPORTS rat without an exercise wheel(sedentary), 3) control rat with an exercise wheel(running), and 4) control rat without an exercise wheel(sedentary). Heart rate was significantly increased in sedentary SPORTS rats compared to those in control rats. SPORTS rats show a significant reduction in resting heart rate by high-intensity running. The low frequency/high frequency(LF/HF) ratio, which reflects cardiac sympathetic nerve activity, was significantly decreased in SPORTS rats by voluntary running. However, a decrease of sympathetic nerve activity was not observed in control rats with approximately 1/10 wheel-running activity. By wheel running, the low frequency(LF) power was augmented in control rats, and was markedly depressed in SPORTS rats. High-intensity voluntary running decreases mean heart rate during resting period(sedentary) with a depression of sympathetic nerve activity. These results suggest that high-intensity voluntary exercise attenuates sympathetic nerve activity not only during exercise but also during resting period as a lasting effects.

我们建立了一种新的大鼠品系，其特征是高水平的自愿车轮运行，这是所谓的运动（自发运行德岛四国）大鼠。本研究的目的是探讨高强度或低强度的自愿运动对心脏的交感神经和迷走神经的控制，在静坐和车轮运行的运动中使用的运动大鼠。在15周龄时，将每只大鼠移至具有或不具有运动轮的新笼中，并分为四组：1）具有运动轮的SPORTS大鼠（跑步），2）不具有运动轮的SPORTS大鼠（久坐），3）具有运动轮的对照大鼠（跑步），和4）不具有运动轮的对照大鼠（久坐）。与对照组大鼠相比，久坐运动大鼠的心率显著增加。SPORTS大鼠在高强度跑步后静息心率显著降低。自发运动可使反映心脏交感神经活动的低频/高频比值（LF/HF）显著降低。然而，在对照组大鼠中未观察到交感神经活动的减少，约为1/10的轮跑活动。通过转轮跑，低频（LF）功率在对照组大鼠增加，并在运动大鼠明显抑制。高强度的自主跑步会降低静息期（久坐）的平均心率，同时抑制交感神经活动。这些结果表明，高强度的随意运动不仅在运动期间，而且在休息期间，交感神经活动衰减作为一个持久的影响。