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Establishment of molecular mechanism of exercise motivation using a novel rat-strain featured by high levels of wheel-running activity

利用高轮跑活动水平的新型大鼠品系建立运动动机的分子机制

基本信息

批准号：
21700696
负责人：
MORISHIMA Masaki
金额：
$ 2.25万
依托单位：
Oita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

We established a novel rat strain featured by high levels of voluntary wheel-running, which is called SPORTS(Spontaneously-Running Tokushima-Shikoku) rat. The aim of this study was to investigate the effect of high-or low-intensities in voluntary exercise on sympathetic and vagal controls of heart at sedentary and during wheel-running exercise by use of SPORTS rats. At 15 weeks of age, each rat was moved to a new cage with or without an exercise wheel, and sorted into four groups ; 1) SPORTS rat with an exercise wheel(running), 2) SPORTS rat without an exercise wheel(sedentary), 3) control rat with an exercise wheel(running), and 4) control rat without an exercise wheel(sedentary). Heart rate was significantly increased in sedentary SPORTS rats compared to those in control rats. SPORTS rats show a significant reduction in resting heart rate by high-intensity running. The low frequency/high frequency(LF/HF) ratio, which reflects cardiac sympathetic nerve activity, was significantly decreased in SPORTS rats by voluntary running. However, a decrease of sympathetic nerve activity was not observed in control rats with approximately 1/10 wheel-running activity. By wheel running, the low frequency(LF) power was augmented in control rats, and was markedly depressed in SPORTS rats. High-intensity voluntary running decreases mean heart rate during resting period(sedentary) with a depression of sympathetic nerve activity. These results suggest that high-intensity voluntary exercise attenuates sympathetic nerve activity not only during exercise but also during resting period as a lasting effects.

我们建立了一种新的以高水平自愿跑轮为特征的大鼠品系，称为SPORTS(自发跑步德岛-四国)大鼠。本研究的目的是利用运动大鼠，观察高强度和低强度运动对运动大鼠安静运动和跑轮运动时心脏交感神经和迷走神经控制的影响。在15周龄时，每只大鼠被移到一个有或没有运动轮的新笼子里，并被分成四组：1)运动大鼠有运动轮(跑步)，2)运动大鼠不带运动轮(久坐)，3)对照大鼠有运动轮(跑步)，4)对照大鼠没有运动轮(久坐)。与对照组相比，久坐运动组大鼠的心率显著增加。运动大鼠的静息心率因高强度跑步而显著降低。运动大鼠自主运动后，反映心脏交感神经活动的低频/高频比值(LF/HF)显著降低。然而，在大约1/10轮子活动的对照组大鼠中，没有观察到交感神经活性的下降。通过滚轮运动，对照组大鼠低频功率明显增加，运动组大鼠低频功率显著降低。高强度的自愿跑步降低了静息期(久坐)的平均心率，并抑制了交感神经活动。这些结果表明，高强度的自愿运动不仅在运动期间减弱交感神经活动，而且在静息期也是如此，这是一种持久的影响。