The novel effect of polyphenolic diterpene in rosemary, activating oxidative stress sensor

本研究考察了鼠尾草酸（CA）激活迷迭香中多酚二萜Keap1/Nrf2通路对血管生成的影响。CA在体外无血清大鼠主动脉基质培养模型中抑制微血管生长。在人脐静脉内皮细胞血管生成模型中，从重建基膜上的管形成、增殖和趋化性等方面显示了CA的抗血管生成作用。这些结果表明，CA可能有助于预防和治疗血管生成依赖性疾病。

In this study, the effect of carnosic acid (CA) activating Keap1/Nrf2 pathway, a polyphenolic diterpene in rosemary, on angiogenesis was examined. CA suppressed microvessel outgrowth in an ex vivo serum-free matrix culture model using a rat aortic. The antiangiogenic effect of CA was shown in angiogenesis models using human umbilical vein endothelial cells with regard to tube formation on reconstituted basement membrane, proliferation and chemotaxis. These results suggest that CA may be useful for prevention and treatment of angiogenesis-dependent disorders.