Influence on the raise of blood glucose and insulin secretion by AMP oral ingestion

口服AMP对血糖升高和胰岛素分泌的影响

• 批准号: 21700766
• 负责人: KIYAMA Atsuko
• 金额: $ 2.66万
• 依托单位: Kyoto Women's University (2011)Yasuda Women's University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700766/
• 关键词: 栄養生理; 栄養補助成分; AMP

AMP activated kinase(AMPK) is a enzyme that plays a important role in cellular energy homeostasis. In this study, I examined the oral ingestion of AMP which is the substrate of AMPK, effect on the raise of blood glucose and insulin secretion in the mice, and the glucose uptake to IEC-6 cell from medium with AMP+/-. But in this experiment, the difference of AMP(+) or(-) does not become clear.

AMP活化激酶（AMPK）是一种在细胞能量稳态中起重要作用的酶。在本研究中，我检测了口服AMPK的底物AMP对小鼠血糖和胰岛素分泌的影响，以及AMP+/-培养基对IEC-6细胞的葡萄糖摄取。但在本实验中，AMP（+）或（-）的区别并不明显。