Studies on search and action mechanism of new functional substances of a constituent of Porphyra yezoensis

条斑紫菜成分新功能物质的寻找及作用机制研究

• 批准号: 21700768
• 负责人: TOMOYORI Hiroko
• 金额: $ 5.67万
• 依托单位: Prefectural University of Kumamoto
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700768/
• 关键词: 糖尿病; 低栄養; 機能性食品; 海藻; 海苔; 栄養学; 食品; 脂質

In order to clarify the effect on the lipid absorption of Nori, we administered Nori sample to rats. The sample was obtained by heating rapeseed oil and Nori fine powder (RNAO). The lipid concentration in the blood compared to the control group, RNAO were high. Therefore, in order to reveal the agent, we subjected to a lipid load test using water-soluble dietary fiber (porphyran) extracted from Nori, unexpectedly lipid absorption was inhibited. Moreover, this effect was investigated whether it was depended on the viscosity of Nori solution. It was shown that it is not intended to promote lipid absorption by the viscosity. These results were measured lipid level in blood. In order to evaluate more accurately, the next experiment was examined absorption into the lymph. As a result, lymph flow and the phospholipid concentration were not influenced, but lipid concentration became higher. These observations suggest that RNAO may promote the lipid absorption. Further, we advanced the separation and purification of the insulin-like action substance from Nori, but did not lead to identification of the active substance

为了阐明紫菜对脂质吸收的影响，我们给大鼠喂紫菜样品。样品由菜籽油和紫菜细粉（RNAO）加热得到。血液中脂质浓度与对照组相比，RNAO均较高。因此，为了揭示这一因素，我们用紫菜中提取的水溶性膳食纤维（卟啉）进行了脂质负荷试验，没想到脂质吸收被抑制了。并考察了这种影响是否与紫菜溶液的黏度有关。结果表明，粘稠度并不能促进脂质吸收。这些结果测量了血液中的脂质水平。为了更准确地评估，下一个实验是检查吸收进入淋巴。结果，淋巴流量和磷脂浓度不受影响，但脂质浓度升高。这些观察结果表明RNAO可能促进脂质吸收。此外，我们进一步从紫菜中分离纯化了胰岛素样作用物质，但没有得到有效物质的鉴定

项目成果

スサビノリ由来成分の脂質吸収促進作用に関する研究

紫菜来源成分促进脂质吸收作用的研究

• 发表时间: 2011
• 作者: 友寄博子;近藤昌次;淺川牧夫
• 通讯作者: 淺川牧夫

スサビノリ由来成分のインスリン様作用

须须紫菜成分的类胰岛素作用

• 发表时间: 2010
• 作者: 友寄博子;近藤昌次;淺川牧夫
• 通讯作者: 淺川牧夫

海藻由来成分のインスリン様作用

海藻成分的类胰岛素作用

• 发表时间: 2010
• 作者: 友寄博子;淺川牧夫
• 通讯作者: 淺川牧夫