Intracellular manipulation of proteins in neurons with resonance laser beam

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Biological systems form complex networks related with functional molecules and are dynamically affected by spatio-temporal regulations. For aiming artificial control of the systems, we proposed and demonstrated intracellular manipulation of neural cell adhesion molecules(NCAMs) on living neuronal cells using resonance and nonresonance laser beams. The intracellular motion of NCAMs labeled with quantum dots was evaluated by fluorescence correlation spectroscopy.