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Strategy for the early prevention of sarcopenia and its effects on community-dwelling elderly people

肌肉减少症的早期预防策略及其对社区老年人的影响

基本信息

批准号：
22300243
负责人：
KIM Hunkyung
金额：
$ 9.82万
依托单位：
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

The prevalence of sarcopenia was 22.1% in community-dwelling elderly women. The comparison of several variables between the sarcopenic and normal group shows that sarcopenic women had significantly lower calf girth, bone mineral density, BMI, and muscle mass, and were older. Additionally, sarcopenic women had a higher history of osteoporosis, falls, and fractures rates compared with normal subjects. To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass and strength in community-dwelling elderly sarcopenic women. One hundred fifty-five women aged 75 and older were defined as sarcopenic and randomly assigned to one of four groups : exercise and amino acid supplementation (exercise + AAS; n = 38), exercise (n = 39), amino acid supplementation (AAS; n = 39), or health education (HE; n = 39). The exercise group attended a 60-minute comprehensive training program twice a week, and the AAS group ingested 3 g of a leucine-rich essential amino acid mi … More xture twice a day for 3 months. Body composition was determined using bioelectrical impedance analysis. Data from interviews and functional fitness parameters such as muscle strength and walking ability were collected at baseline and after the 3-month intervention. A significant group × time interaction was seen in leg muscle mass (P = .007), usual walking speed (P = .007), and knee extension strength (P = .017). The within-group analysis showed that walking speed significantly increased in all three intervention groups, leg muscle mass in the exercise + AAS and exercise groups, and knee extension strength only in the exercise + AAS group (9.3% increase, P = .010). The odds ratio for leg muscle mass and knee extension strength improvement was more than four times as great in the exercise + AAS group (odds ratio = 4.89, 95% confidence interval = 1.89-11.27) as in the HE group. The data suggest that exercise and AAS together may be effective in enhancing not only muscle strength, but also combined variables of muscle mass and walking speed and of muscle mass and strength in sarcopenic women. Less

在社区居住的老年妇女中，石棺减少的患病率为22.1%。骨质疏松组和正常组之间的几个变量的比较显示，骨质疏松组女性的小腿围、骨密度、BMI和肌肉质量显著较低，并且年龄较大。此外，与正常受试者相比，骨量减少的女性有更高的骨质疏松症、跌倒和骨折的病史。目的：评价运动和补充氨基酸对社区老年骨肉营养不良妇女肌肉质量和力量的影响。155名75岁及以上的女性被定义为骨质疏松症患者，随机分为4组：运动+氨基酸补充组(n=38)、运动+氨基酸补充组(n=39)、氨基酸补充组(n=39)或健康教育组(n=39)。运动组每周两次参加60分钟的综合训练计划，而AAS组摄入3克富含亮氨酸的必需氨基酸mi…每天两次，持续3个月。用生物电阻抗分析测定身体成分。在基线和干预3个月后收集访谈数据和功能健身参数，如肌肉力量和步行能力。在腿部肌肉质量(P=.007)、平时步行速度(P=.007)和膝关节伸展力量(P=.017)方面存在显著的组×时间交互作用。组内分析显示，3个干预组的步行速度均显著提高，运动+AAS组和运动组的腿部肌肉质量显著增加，只有运动+AAS组的伸膝力量显著增加(9.3%，P=0.010)。运动+AAS组小腿肌肉质量和膝关节伸展力量改善的优势比是HE组的4倍多(优势比=4.89，95%可信区间=1.89~11.27)。这些数据表明，运动和AAS一起可能不仅在增强肌肉力量方面有效，而且在肌肉量和步行速度以及肌肉质量和力量的组合变量方面也是有效的。较少