Significance and Molecular mechanisms of abnormal expression of miRNA in carcinogenesis.

点击翻译按钮获取中文摘要

There have been reported to be about 1000 species of miRNA in human, among them, such miRNAs as miR-21, miR-199a, miR-15/-16 and miR-200c are expressed at aberrant levels in cancer tissues. In this research, we demonstrated how these aberrant expression were induced and maintained, and found in several cases, stable gene regulatory net works have been formed among the miRNA, transcription factors and SWI/SNF chromatin remodeling factors. We further show the RNA decoy molecules that we developed for the inhibitor of specificmicorRNA activity (designated TuD) is very effective for the analysis of molecular mechanisms and for future therapietic application for cancer.