Functional study on the regulatory role of reactive oxygen species-generating oxidase Nox1 in cancer development

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Research effort has been made to investigate the functional role of ROS-generating Nox family enzymes in cancer development. We have found that Nox1 and Nox4 mediate cellular senescence, both Wnt-β-catenin signaling in colon cancer and recovery of inflammantion in the colon epithelium, and that Nox5 is required for adult T -cell leukemia virus-induced transformation. These results further support that Nox-derived ROS play an essential role in carcinogenesis and inflammation and underscore importance of Nox enzymes as therapeutic targets in cancer prevention.