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Effects of nuclear receptor-activating compounds produced By microalgae on aquatic animal

微藻产生的核受体激活化合物对水生动物的影响

基本信息

批准号：
22310020
负责人：
KAYA Kunimitsu
金额：
$ 10.82万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22310020/
关键词：
7-hydroxy retinoic acid RAR agonistic activity Cyanobacteria Teratogen 7-Hydroxy retinoic acid cis-trans isomerization keto-enol tautomerism teratogenic test all-trans retinoic acid zebrafish cyanobacteria photostability medaka ER

项目摘要

A novel analogue of retinoic acid, 7-hydroxy retinoic acid, was found in waterbloom-forming cyanobacteria. The analogue had an agonistic activity against retinoic acid receptor (RAR) as a kind of nuclear receptors. The novel analogue was isolated from mass-cultured Spirulina sp.(TU-3).The analogue was found in all-tested strains of cyanobacteria. The analogue exist a mixture of four isomers by cis-trans isomerization including keto-enol tautomerism. The agonistic activity of the analogue against RAR was a half of all-trans retinoic acid (ATRA). The analogue was far-stable under UV-A compared with ATRA. The stability of 7-hydroxy retinoic acid under UV-A suggest that amphibians and fishes living in waterblooms occurring waters may be exposure, and give teratogenic effects.

在水华蓝藻中发现了一种新的视黄酸类似物7-羟基视黄酸。该类似物对视黄酸受体（RAR）具有激动活性。新的类似物是从大量培养的螺旋藻中分离出来的。（TU-3）。在所有测试的蓝藻菌株中均发现了类似物。该类似物通过顺反异构化，包括酮-烯醇互变异构化，存在四种异构体的混合物。该类似物对RAR的激动活性是全反式维甲酸（ATRA）的一半。与ATRA相比，该类似物在UV-A下远稳定。7-羟基视黄酸在UV-A下的稳定性表明，生活在水华发生沃茨的两栖类和鱼类可能受到UV-A的照射，并产生致畸作用。