Development of supercritical fluid extraction-distillation system for separation of high-value products from Citrus peels

开发了从自然资源中分离高附加值产品的超临界流体萃取-精馏系统。在该系统中，橙皮粉用超临界CO2萃取，并加入乙醇，萃取物被转移到热控蒸馏塔中，在指定的温度和压力下，根据CO2-乙醇体系的汽液相平衡，萃取物成分可以分离到上游和下游。为了对所开发的仪器进行评价，选择了两种具有相似化学结构的物质(7-羟基黄酮和菲)作为测试样品。精馏结果表明，在12 Mpa的压力下，从精馏塔顶部的馏分中，没有7-羟基黄酮伴生，菲高度集中，塔顶温度控制在353K~363K之间。诺比灵是一种活性很高的天然化合物，也是通过添加少量的水夹带剂从顶部浓缩到馏分中的。结果表明，所建立的分离系统能很好地从柑橘果皮中高选择性地分离多甲氧基黄酮。

Supercritical fluid extraction-distillation system for separation of high-value products from natural resources was developed. In this system, orange peel powers were extracted by supercritical CO2 with an addition of ethanol and the extract was transferred to thermally controlled distillation tower in which in which extract constituents could be separated into upstream and downstream according to vapor-liquid phase equilibrium for CO2-ethanol systems at specified temperature and pressure. For evaluation of the developed apparatus, two substances (7-hydroxy flavone and anthracene) possessing the similar chemical structures were selected as test samples. The results of distillation showed that the anthracene was highly concentrated in the distillate from the top of the distillation column without accompanying 7-hydroxy flavone at pressure of 12 MPa and temperatures of the tower controlled to be between 353 K at the top and 363 K at the bottom. Nobilethin is one of the highly active natural compounds was also concentrated in the distillate from the top by adding a slight amount of water entrainers. It was demonstrated that the developed system was well-worked towards the highly-selected separation of polymethoxyflavone from Citrus peels.