Development of supercritical fluid extraction-distillation system for separation of high-value products from Citrus peels

开发用于从柑橘皮中分离高价值产品的超临界流体萃取蒸馏系统

• 批准号: 22360317
• 负责人: INOMATA Hiroshi
• 金额: $ 12.9万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22360317/
• 关键词: (1) 超臨界流体抽出; (2)エタノール; (3)水; (4)ノビレチン; (5)相分離; (6)精留; (7)分画; (8)溶媒循環; 柑橘果皮; 超臨界CO2; 抽出分離; フラボノイド; 精留効果; エタノール; 相分離; 超臨界流体抽出; 水; ノビレチン; 精留; 分画; 超臨界; 天然物; 溶媒循環; 薬効成分

Supercritical fluid extraction-distillation system for separation of high-value products from natural resources was developed. In this system, orange peel powers were extracted by supercritical CO2 with an addition of ethanol and the extract was transferred to thermally controlled distillation tower in which in which extract constituents could be separated into upstream and downstream according to vapor-liquid phase equilibrium for CO2-ethanol systems at specified temperature and pressure. For evaluation of the developed apparatus, two substances (7-hydroxy flavone and anthracene) possessing the similar chemical structures were selected as test samples. The results of distillation showed that the anthracene was highly concentrated in the distillate from the top of the distillation column without accompanying 7-hydroxy flavone at pressure of 12 MPa and temperatures of the tower controlled to be between 353 K at the top and 363 K at the bottom. Nobilethin is one of the highly active natural compounds was also concentrated in the distillate from the top by adding a slight amount of water entrainers. It was demonstrated that the developed system was well-worked towards the highly-selected separation of polymethoxyflavone from Citrus peels.

开发了超临界流体萃取-精馏系统，用于从自然资源中分离高价值产品。在该系统中，橙子皮粉经超临界CO2萃取后，在一定温度和压力下，萃取液进入温控精馏塔，根据CO2-乙醇体系的汽液相平衡，将萃取液组分分离到上游和下游。为了评价所开发的装置，选择具有相似化学结构的两种物质（7-羟基黄酮和蒽）作为测试样品。蒸馏结果表明，在压力为12 MPa，塔顶温度控制在353 K ~ 363 K时，塔顶馏出物中蒽含量高，不伴有7-羟基黄酮。Nobilethin是一种高活性的天然化合物，也可以通过加入少量的水分散剂从塔顶馏出物中浓缩。实验结果表明，该体系能有效地分离柑橘皮中的多甲氧基黄酮。

项目成果

超臨界流体を用いた摘果みかん果皮機能性成分の環境調和型濃縮法

超临界流体环保浓缩薄橘皮功能成分的方法

• 发表时间: 2011
• 作者: Y. Hayakawa;M. Arivanandhan;G. Rajesh;T. Koyama;Y. Momose;H. Morii;T. Aoki;Y. Takagi;Y. Okano;T. Ozawa;K. Sakata and Y. Inatomi;Masaaki Otsu;橋本吉晃,大田昌樹,佐藤善之,猪股宏,大泉康
• 通讯作者: 橋本吉晃,大田昌樹,佐藤善之,猪股宏,大泉康

超臨界CO_2中のフラボノイド溶解度に対するエタノールの添加効果の定量化

超临界CO_2中乙醇添加对类黄酮溶解度影响的量化

• 发表时间: 2010
• 作者: 阪田薫穂;向井碧;Govindasamy Rajesh;Mukannan Arivanandhan;稲富裕光;石川毅彦;早川泰弘,;野村幸一郎,大田昌樹,佐藤善之,猪股宏,大泉康,山國徹;橋本吉晃,大田昌樹,佐藤善之,猪股宏
• 通讯作者: 橋本吉晃,大田昌樹,佐藤善之,猪股宏

9.2超臨界抽出・分離

9.2 超临界萃取/分离

• 发表时间: 2011
• 期刊: 化学工学
• 作者: M. Mizutani;他6名;大田昌樹
• 通讯作者: 大田昌樹

天然物のカスケード利用における超臨界流体抽出

超临界流体萃取在天然产物梯级利用中的应用

• 发表时间: 2012
• 作者: I. Narita;Y. Fuchigami;Y. Nakamura;T. Uchino;M. Kamezaki;C. Ishibashi;H. Miyahara;Ikuo Ihara (共著);大田昌樹
• 通讯作者: 大田昌樹

Supercritical Fluid Fractionation of Bioactive Compounds Contained in Orange Peels

橙皮中生物活性化合物的超临界流体分离

• 发表时间: 2012
• 作者: 内野隆志;淵上遥平;成田一人;宮原広郁;大津雅亮;Masaaki Otsu;Hiroshi Inomata
• 通讯作者: Hiroshi Inomata