Formation of three-dimensional vascularized tissue by multi-scale operation and application to regenerative medicine

多尺度操作形成三维血管化组织及其在再生医学中的应用

• 批准号: 22360347
• 负责人: KAJIWARA Toshihisa
• 金额: $ 10.57万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22360347/
• 关键词: 医用化学工学; 再生医療; 三次元培養; 血化組織; 肝細胞; 血管内皮細胞; 血管新生; 共培養

Tissue vascularization in vitro is necessary for cell transplantation and is a major challenge in tissue engineering. To construct large and regularly vascularized tissue, we focused on the integration of endothelial cell幼overed spheroids. To construct re

Tissue vascularization in vitro is necessary for cell transplantation and is a major challenge in tissue engineering. To construct large and regularly vascularized tissue, we focused on the integration of endothelial cell immature spores. To construct re

项目成果

中空糸を用いた幹細胞分化・細胞組織構築技術の開発

利用中空纤维开发干细胞分化和细胞组织构建技术

• 发表时间: 2011
• 作者: J.Kurokawa;M.Asano;S.Nomoto;Y.Makino;N.Itoh;Suguru Takada;尾島由紘,芦田知亮,楠田綾子,紀ノ岡正博,田谷正仁;水本博,中澤浩二,井嶋博之,船津和守,梶原稔尚
• 通讯作者: 水本博,中澤浩二,井嶋博之,船津和守,梶原稔尚

多能性幹細胞を利用した人工肝補助療法としてのバイオ人工肝臓デバイス開発

利用多能干细胞开发生物人工肝装置作为人工肝辅助治疗

• 发表时间: 2012
• 作者: Nagai;K. Iida;K. Shimizu;K. Kinugasa;R. Izumi;M. Kato;D. Takeo;M. Mochiji;K. & Negoro S.;水本博,網本直記,中澤浩二,井嶋博之,船津和守,梶原稔尚
• 通讯作者: 水本博,網本直記,中澤浩二,井嶋博之,船津和守,梶原稔尚

Hepatic Differentiation of Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells During Organoid Formation in Hollow Fibers

• DOI: 10.1089/ten.tea.2010.0689
• 发表时间: 2011-08-01
• 期刊: TISSUE ENGINEERING PART A
• 影响因子: 4.1
• 作者: Amimoto, Naoki;Mizumoto, Hiroshi;Kajiwara, Toshihisa
• 通讯作者: Kajiwara, Toshihisa

Investigation of medium perfusion through scaffold-free tissue constructs using endothelial cell-covered spheroids in vitro

• DOI: 10.1016/j.bej.2010.04.004
• 发表时间: 2010-07-15
• 期刊: BIOCHEMICAL ENGINEERING JOURNAL
• 影响因子: 3.9
• 作者: Inamori, Masakazu;Mizumoto, Hiroshi;Kajiwara, Toshihisa
• 通讯作者: Kajiwara, Toshihisa

Formation of a multicellular organoid and hepatic differentiation of human induced pluripotent stem cells inside hollow fiber

中空纤维内多细胞类器官的形成及人诱导多能干细胞的肝分化

• 作者: Yoshiaki Horita;Toru Miyazawa;Naoki Amimoto;Hiroshi Mizumoto;Kohji Nakazawa;Hiroyuki Ijima;Kazumori Funatsu;Toshihisa Kajiwara
• 通讯作者: Toshihisa Kajiwara