Integrin dependent cellular growth and functions through the mammalianhippo pathway

通过哺乳动物河马途径整合素依赖性细胞生长和功能

• 批准号: 22370072
• 负责人: KINASHI Tatsuo
• 金额: $ 12.23万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22370072/
• 关键词: Mst1,Mst2,インテグリン; Outside-in シグナル; Rap1; Mst1; Mat2; インテグリン; Mst2; Outside-inシグナル

Mst1/Mst2, Mammalian homolog of Hippo associates with Rap1 effector RAPL and regulates lymphocyte adhesion and migration through leukocyte integrin LFA-1. Furthermore, RAPL negatively regulate cell cycle through G1 cyclin inhibitor p27Kip1. In addition, tissue imaging analysis has revealed that Mst1 is required for efficient thymocyte trafficking and selection. Consequently, deficiencies of RAPL and Mst1 lead to lymphoproliferative and autoimmune-like disorders.

Mst 1/Mst 2是Hippo的哺乳动物同源物，与Rap 1效应子RAPL相关，并通过白细胞整合素LFA-1调节淋巴细胞粘附和迁移。RAPL还通过G1期细胞周期蛋白抑制剂p27 Kip 1负调控细胞周期。此外，组织成像分析表明，Mst 1是有效的胸腺细胞运输和选择所必需的。因此，RAPL和Mst 1的缺陷导致淋巴组织增生性和自身免疫样疾病。

项目成果

免疫細胞の組織内移動と停止の制御：イメージング手法による接着制御の解析

组织迁移的控制和免疫细胞的停滞：使用成像方法分析粘附控制

• 作者: 片山勉;他;木梨達雄
• 通讯作者: 木梨達雄

Distinct signaling processes in regulation of lymphocyte arrest and adhesion strengthening under shear flow

剪切流下调节淋巴细胞停滞和粘附强化的独特信号传导过程

• 发表时间: 2010
• 作者: Fujimitsu;K.;他;三原勝芳;Kinashi.T.
• 通讯作者: Kinashi.T.

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus

• DOI: 10.1038/ncomms2105
• 发表时间: 2012-10-01
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Ueda, Yoshihiro;Katagiri, Koko;Kinashi, Tatsuo
• 通讯作者: Kinashi, Tatsuo

Mst1 regulates thymocyte trafficking and antigen recognition within thymic tissues

Mst1 调节胸腺组织内的胸腺细胞运输和抗原识别

• 发表时间: 2011
• 作者: Ueda Yoshihiro1;Katagiri Koko2;Tomiyama Takashi1;Yasuda Kaneki1;Habiro Katsuyoshi1;Katakai Tomoya1;Ikehara Susumu3;Kinashi Tatsuo1;(1Department of Molecular Genetics;Institute of Biomedical Science;Kansai Medical University. 2Department of Biosc
• 通讯作者: Kansai Medical University. 2Department of Biosc

Distinct signaling processes in regulation of lymphocyte arrest and adhesi on strengthening under shear flow

剪切流下淋巴细胞停滞和粘附增强调节中的独特信号传导过程

• 发表时间: 2010
• 作者: T.Kinashi;K.Katagiri;T.Katakai;Y.Ueda
• 通讯作者: Y.Ueda