Integrin dependent cellular growth and functions through the mammalianhippo pathway

Mst 1/Mst 2是Hippo的哺乳动物同源物，与Rap 1效应子RAPL相关，并通过白细胞整合素LFA-1调节淋巴细胞粘附和迁移。RAPL还通过G1期细胞周期蛋白抑制剂p27 Kip 1负调控细胞周期。此外，组织成像分析表明，Mst 1是有效的胸腺细胞运输和选择所必需的。因此，RAPL和Mst 1的缺陷导致淋巴组织增生性和自身免疫样疾病。

Mst1/Mst2, Mammalian homolog of Hippo associates with Rap1 effector RAPL and regulates lymphocyte adhesion and migration through leukocyte integrin LFA-1. Furthermore, RAPL negatively regulate cell cycle through G1 cyclin inhibitor p27Kip1. In addition, tissue imaging analysis has revealed that Mst1 is required for efficient thymocyte trafficking and selection. Consequently, deficiencies of RAPL and Mst1 lead to lymphoproliferative and autoimmune-like disorders.